All in the Family: Understanding a New Class of Bacterial Toxins

Distant relatives of a eukaryotic cell-specific toxin family evolved a complement-like mechanism to kill bacteria

HL Abrahamsen, TC Sanford, CE Collamore, BA Johnstone, MJ Coyne, L García-Bayona, MP Christie, JC Evans, AJ Farrand, K Flores, CJ Morton, MW Parker, LE Comstock, RK Tweten

2024-12-01

Cholesterol-dependent cytolysins (CDCs) comprise a large family of pore-forming toxins produced by Gram-positive bacteria, which a..